POS1240 HYDROXYCHLOROQUINE CARDIOTOXICITY: A CASE-CONTROL STUDY COMPARING PATIENTS WITH COVID19 AND PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
نویسندگان
چکیده
Background: Antimalarials have been associated with QT prolongation in COVID19 patients but are generally safe rheumatologic disease. Objectives: Aim of the study was to compare prevalence QTc between and Systemic Lupus Erythematosus (SLE) treated hydroxychloroquine (HCQ). Methods: We included consecutive SARS-CoV-2 infection confirmed by nasopharyngeal swab taking HCQ for SLE. A prolonged defined as an increase intervals >60 ms (compared baseline) or a ≥500 ms. Results: enrolled 58 (median age 70.5 years, IQR 25). HCQ, without azithromycin, given 26 (44.8%) 15 (25.9%), respectively; 17 (29.3%) had not received either drug. The median baseline 432 (IQR 36) observed (26%) (12 QTc≥500 3 ΔQTc>60 ms). didn’t find significant differences among three treatment groups. Baseline (OR 111.5) D-dimer 78.3) were independently prolongation. Compared 50 SLE 38.5 22), chronically showed significantly longer (p < 0.001) (Table 1). Conclusion: This is first demonstrating that, differently from patients, susceptible HCQ-induced long syndrome arrhythmia. combined arrhythmogenic effect could account excess fatal arrhythmias described COVID19. Table 1. Difference clinical demographic features patients. Demographic Features Covid-19 p-Value N° Female 43 23 0.001 Age (years) 45 (17) (25) Comorbidities N % Hypertension (30) 24 (48) 0.2 Cardiovascular diseses 8 (16) 13 (22.4) 0.4 COPD 1 (2) 9 (15.5) 0.016 Thyroid disease (13.8) 0.75 Chronic kidney 4 (8) 5 (8.6) 0.91 Population characteristics Median ) (mg/die) 400 (125) Time (days) 3255 (5790) 7 (ms) SLEDAI-2K SDI (36.25) 0 (4) 395 (80) - Disclosure Interests: None declared
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2021
ISSN: ['1468-2060', '0003-4967']
DOI: https://doi.org/10.1136/annrheumdis-2021-eular.3228